Minocycline Prevents Depression-like Behavior After Co-administration With Dexamethasone or Cyclosporine-A in Mice

Background: In animal studies, minocycline (Mcy) has been proven to have antidepressant effects. addition modulating peripheral and central pro-inflammatory pathways, Mcy may regulate the hypothalamic-pituitary-adrenal (HPA) axis mechanistic target of rapamycin (mTOR) signaling pathway. This study aims evaluate antidepressant-like effect in mice following injection dexamethasone (Dex) or cyclosporine-A (CsA). Methods: Male NMRI were randomly divided into eight groups 6, including control, Dex 0.25 mg/kg, CsA 20 40 Dex+Mcy, Dex+fluoxetine CsA+Mcy, CsA+fluoxetine. All drugs injected intraperitoneally (except for Dex, which was subcutaneous injection) once daily 3 days. The locomotor activity, forced swimming test (FST), sucrose preference (SP) performed on day 4. Results: alone reduced immobility time FST (27.0±6.4 s) compared control group (104±3.9 (P<0.001). After co-administration significantly decreased (79.5±6.5 It also (67.5±20.8 Results similar treated with fluoxetine plus CsA. Significant differences not observed activity test. Conclusion: prevents depression-like behavior during when it is co-administrated Dex. possibility positive HPA mTOR pathway should be examined further studies.